Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targets them for proteasomal degradation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Annie M. Sriramachandran, Katrin Meyer-Teschendorf, Stefan Pabst, Helle D. Ulrich, Niels H. Gehring, Kay Hofmann, Gerrit J. K. Praefcke, R. Jürgen Dohmen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0762ab2824541ce8ce0b7085be1b113
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0762ab2824541ce8ce0b7085be1b113
record_format	dspace
spelling	oai:doaj.org-article:d0762ab2824541ce8ce0b7085be1b1132021-12-02T14:39:58ZArkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain10.1038/s41467-019-11549-32041-1723https://doaj.org/article/d0762ab2824541ce8ce0b7085be1b1132019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11549-3https://doaj.org/toc/2041-1723The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targets them for proteasomal degradation.Annie M. SriramachandranKatrin Meyer-TeschendorfStefan PabstHelle D. UlrichNiels H. GehringKay HofmannGerrit J. K. PraefckeR. Jürgen DohmenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annie M. Sriramachandran Katrin Meyer-Teschendorf Stefan Pabst Helle D. Ulrich Niels H. Gehring Kay Hofmann Gerrit J. K. Praefcke R. Jürgen Dohmen Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain
description	The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targets them for proteasomal degradation.
format	article
author	Annie M. Sriramachandran Katrin Meyer-Teschendorf Stefan Pabst Helle D. Ulrich Niels H. Gehring Kay Hofmann Gerrit J. K. Praefcke R. Jürgen Dohmen
author_facet	Annie M. Sriramachandran Katrin Meyer-Teschendorf Stefan Pabst Helle D. Ulrich Niels H. Gehring Kay Hofmann Gerrit J. K. Praefcke R. Jürgen Dohmen
author_sort	Annie M. Sriramachandran
title	Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain
title_short	Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain
title_full	Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain
title_fullStr	Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain
title_full_unstemmed	Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain
title_sort	arkadia/rnf111 is a sumo-targeted ubiquitin ligase with preference for substrates marked with sumo1-capped sumo2/3 chain
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d0762ab2824541ce8ce0b7085be1b113
work_keys_str_mv	AT anniemsriramachandran arkadiarnf111isasumotargetedubiquitinligasewithpreferenceforsubstratesmarkedwithsumo1cappedsumo23chain AT katrinmeyerteschendorf arkadiarnf111isasumotargetedubiquitinligasewithpreferenceforsubstratesmarkedwithsumo1cappedsumo23chain AT stefanpabst arkadiarnf111isasumotargetedubiquitinligasewithpreferenceforsubstratesmarkedwithsumo1cappedsumo23chain AT helledulrich arkadiarnf111isasumotargetedubiquitinligasewithpreferenceforsubstratesmarkedwithsumo1cappedsumo23chain AT nielshgehring arkadiarnf111isasumotargetedubiquitinligasewithpreferenceforsubstratesmarkedwithsumo1cappedsumo23chain AT kayhofmann arkadiarnf111isasumotargetedubiquitinligasewithpreferenceforsubstratesmarkedwithsumo1cappedsumo23chain AT gerritjkpraefcke arkadiarnf111isasumotargetedubiquitinligasewithpreferenceforsubstratesmarkedwithsumo1cappedsumo23chain AT rjurgendohmen arkadiarnf111isasumotargetedubiquitinligasewithpreferenceforsubstratesmarkedwithsumo1cappedsumo23chain
_version_	1718390444272910336

Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

Ejemplares similares