Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.

Chronic adipose tissue inflammation is a hallmark of obesity-induced insulin resistance and anti-inflammatory agents can benefit patients with obesity-associated syndromes. Currently available type I interferons for therapeutic immunomodulation are accompanied by high cytotoxicity and therefore in t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wei Ying, Srikanth Kanameni, Cheng-An Chang, Vijayalekshmi Nair, Stephen Safe, Fuller W Bazer, Beiyan Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0881167d56545139c0db1b89418b02a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0881167d56545139c0db1b89418b02a
record_format	dspace
spelling	oai:doaj.org-article:d0881167d56545139c0db1b89418b02a2021-11-18T08:16:46ZInterferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.1932-620310.1371/journal.pone.0098835https://doaj.org/article/d0881167d56545139c0db1b89418b02a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24905566/?tool=EBIhttps://doaj.org/toc/1932-6203Chronic adipose tissue inflammation is a hallmark of obesity-induced insulin resistance and anti-inflammatory agents can benefit patients with obesity-associated syndromes. Currently available type I interferons for therapeutic immunomodulation are accompanied by high cytotoxicity and therefore in this study we have examined anti-inflammatory effects of interferon tau (IFNT), a member of the type I interferon family with low cellular toxicity even at high doses. Using a diet-induced obesity mouse model, we observed enhanced insulin sensitivity in obese mice administered IFNT compared to control mice, which was accompanied by a significant decrease in secretion of proinflammatory cytokines and elevated anti-inflammatory macrophages (M2) in adipose tissue. Further investigations revealed that IFNT is a potent regulator of macrophage activation that favors anti-inflammatory responses as evidenced by activation of associated surface antigens, production of anti-inflammatory cytokines, and activation of selective cell signaling pathways. Thus, our study demonstrates, for the first time, that IFNT can significantly mitigate obesity-associated systemic insulin resistance and tissue inflammation by controlling macrophage polarization, and thus IFNT can be a novel bio-therapeutic agent for treating obesity-associated syndromes and type 2 diabetes.Wei YingSrikanth KanameniCheng-An ChangVijayalekshmi NairStephen SafeFuller W BazerBeiyan ZhouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98835 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Ying Srikanth Kanameni Cheng-An Chang Vijayalekshmi Nair Stephen Safe Fuller W Bazer Beiyan Zhou Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.
description	Chronic adipose tissue inflammation is a hallmark of obesity-induced insulin resistance and anti-inflammatory agents can benefit patients with obesity-associated syndromes. Currently available type I interferons for therapeutic immunomodulation are accompanied by high cytotoxicity and therefore in this study we have examined anti-inflammatory effects of interferon tau (IFNT), a member of the type I interferon family with low cellular toxicity even at high doses. Using a diet-induced obesity mouse model, we observed enhanced insulin sensitivity in obese mice administered IFNT compared to control mice, which was accompanied by a significant decrease in secretion of proinflammatory cytokines and elevated anti-inflammatory macrophages (M2) in adipose tissue. Further investigations revealed that IFNT is a potent regulator of macrophage activation that favors anti-inflammatory responses as evidenced by activation of associated surface antigens, production of anti-inflammatory cytokines, and activation of selective cell signaling pathways. Thus, our study demonstrates, for the first time, that IFNT can significantly mitigate obesity-associated systemic insulin resistance and tissue inflammation by controlling macrophage polarization, and thus IFNT can be a novel bio-therapeutic agent for treating obesity-associated syndromes and type 2 diabetes.
format	article
author	Wei Ying Srikanth Kanameni Cheng-An Chang Vijayalekshmi Nair Stephen Safe Fuller W Bazer Beiyan Zhou
author_facet	Wei Ying Srikanth Kanameni Cheng-An Chang Vijayalekshmi Nair Stephen Safe Fuller W Bazer Beiyan Zhou
author_sort	Wei Ying
title	Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.
title_short	Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.
title_full	Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.
title_fullStr	Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.
title_full_unstemmed	Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.
title_sort	interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d0881167d56545139c0db1b89418b02a
work_keys_str_mv	AT weiying interferontaualleviatesobesityinducedadiposetissueinflammationandinsulinresistancebyregulatingmacrophagepolarization AT srikanthkanameni interferontaualleviatesobesityinducedadiposetissueinflammationandinsulinresistancebyregulatingmacrophagepolarization AT chenganchang interferontaualleviatesobesityinducedadiposetissueinflammationandinsulinresistancebyregulatingmacrophagepolarization AT vijayalekshminair interferontaualleviatesobesityinducedadiposetissueinflammationandinsulinresistancebyregulatingmacrophagepolarization AT stephensafe interferontaualleviatesobesityinducedadiposetissueinflammationandinsulinresistancebyregulatingmacrophagepolarization AT fullerwbazer interferontaualleviatesobesityinducedadiposetissueinflammationandinsulinresistancebyregulatingmacrophagepolarization AT beiyanzhou interferontaualleviatesobesityinducedadiposetissueinflammationandinsulinresistancebyregulatingmacrophagepolarization
_version_	1718422013944528896

Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.

Ejemplares similares