TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome translocations from DSBs introduced during ge...

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Autores principales:	Fernando Gómez-Herreros, Guido Zagnoli-Vieira, Ioanna Ntai, María Isabel Martínez-Macías, Rhona M. Anderson, Andrés Herrero-Ruíz, Keith W. Caldecott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d099d05d2c184826b76c100d842728a2
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spelling	oai:doaj.org-article:d099d05d2c184826b76c100d842728a22021-12-02T13:57:32ZTDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription10.1038/s41467-017-00307-y2041-1723https://doaj.org/article/d099d05d2c184826b76c100d842728a22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00307-yhttps://doaj.org/toc/2041-1723DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome translocations from DSBs introduced during gene transcription.Fernando Gómez-HerrerosGuido Zagnoli-VieiraIoanna NtaiMaría Isabel Martínez-MacíasRhona M. AndersonAndrés Herrero-RuízKeith W. CaldecottNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fernando Gómez-Herreros Guido Zagnoli-Vieira Ioanna Ntai María Isabel Martínez-Macías Rhona M. Anderson Andrés Herrero-Ruíz Keith W. Caldecott TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
description	DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome translocations from DSBs introduced during gene transcription.
format	article
author	Fernando Gómez-Herreros Guido Zagnoli-Vieira Ioanna Ntai María Isabel Martínez-Macías Rhona M. Anderson Andrés Herrero-Ruíz Keith W. Caldecott
author_facet	Fernando Gómez-Herreros Guido Zagnoli-Vieira Ioanna Ntai María Isabel Martínez-Macías Rhona M. Anderson Andrés Herrero-Ruíz Keith W. Caldecott
author_sort	Fernando Gómez-Herreros
title	TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
title_short	TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
title_full	TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
title_fullStr	TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
title_full_unstemmed	TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
title_sort	tdp2 suppresses chromosomal translocations induced by dna topoisomerase ii during gene transcription
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d099d05d2c184826b76c100d842728a2
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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

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