A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is efficient in Plasmodiummouse models.

Guardado en:
Detalles Bibliográficos
Autores principales: Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d0b09995908d4fd1a466aa398f702f2f
record_format dspace
spelling oai:doaj.org-article:d0b09995908d4fd1a466aa398f702f2f2021-12-02T15:38:53ZA tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance10.1038/ncomms151592041-1723https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15159https://doaj.org/toc/2041-1723Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is efficient in Plasmodiummouse models.Paul M. O’NeillRichard K. AmewuSusan A. CharmanSunil SabbaniNina F. GnädigJudith StraimerDavid A. FidockEmma R. ShoreNatalie L. RobertsMichael H.-L. WongW. David HongChandrakala PidathalaChris RileyBen MurphyGhaith AljayyoussiFrancisco Javier GamoLaura SanzJanneth RodriguesCarolina Gonzalez CortesEsperanza HerrerosIñigo Angulo-BarturénMaría Belén Jiménez-DíazSantiago Ferrer BazagaMaría Santos Martínez-MartínezBrice CampoRaman SharmaEileen RyanDavid M. ShacklefordSimon CampbellDennis A. SmithGrennady WirjanataRintis NoviyantiRic N. PriceJutta MarfurtMichael J. PalmerIan M. CoppleAmy E. MercerAndrea RueckerMichael J. DelvesRobert E. SindenPeter SieglJill DaviesRosemary RochfordClemens H. M. KockenAnne-Marie ZeemanGemma L. NixonGiancarlo A. BiaginiStephen A. WardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Paul M. O’Neill
Richard K. Amewu
Susan A. Charman
Sunil Sabbani
Nina F. Gnädig
Judith Straimer
David A. Fidock
Emma R. Shore
Natalie L. Roberts
Michael H.-L. Wong
W. David Hong
Chandrakala Pidathala
Chris Riley
Ben Murphy
Ghaith Aljayyoussi
Francisco Javier Gamo
Laura Sanz
Janneth Rodrigues
Carolina Gonzalez Cortes
Esperanza Herreros
Iñigo Angulo-Barturén
María Belén Jiménez-Díaz
Santiago Ferrer Bazaga
María Santos Martínez-Martínez
Brice Campo
Raman Sharma
Eileen Ryan
David M. Shackleford
Simon Campbell
Dennis A. Smith
Grennady Wirjanata
Rintis Noviyanti
Ric N. Price
Jutta Marfurt
Michael J. Palmer
Ian M. Copple
Amy E. Mercer
Andrea Ruecker
Michael J. Delves
Robert E. Sinden
Peter Siegl
Jill Davies
Rosemary Rochford
Clemens H. M. Kocken
Anne-Marie Zeeman
Gemma L. Nixon
Giancarlo A. Biagini
Stephen A. Ward
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
description Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is efficient in Plasmodiummouse models.
format article
author Paul M. O’Neill
Richard K. Amewu
Susan A. Charman
Sunil Sabbani
Nina F. Gnädig
Judith Straimer
David A. Fidock
Emma R. Shore
Natalie L. Roberts
Michael H.-L. Wong
W. David Hong
Chandrakala Pidathala
Chris Riley
Ben Murphy
Ghaith Aljayyoussi
Francisco Javier Gamo
Laura Sanz
Janneth Rodrigues
Carolina Gonzalez Cortes
Esperanza Herreros
Iñigo Angulo-Barturén
María Belén Jiménez-Díaz
Santiago Ferrer Bazaga
María Santos Martínez-Martínez
Brice Campo
Raman Sharma
Eileen Ryan
David M. Shackleford
Simon Campbell
Dennis A. Smith
Grennady Wirjanata
Rintis Noviyanti
Ric N. Price
Jutta Marfurt
Michael J. Palmer
Ian M. Copple
Amy E. Mercer
Andrea Ruecker
Michael J. Delves
Robert E. Sinden
Peter Siegl
Jill Davies
Rosemary Rochford
Clemens H. M. Kocken
Anne-Marie Zeeman
Gemma L. Nixon
Giancarlo A. Biagini
Stephen A. Ward
author_facet Paul M. O’Neill
Richard K. Amewu
Susan A. Charman
Sunil Sabbani
Nina F. Gnädig
Judith Straimer
David A. Fidock
Emma R. Shore
Natalie L. Roberts
Michael H.-L. Wong
W. David Hong
Chandrakala Pidathala
Chris Riley
Ben Murphy
Ghaith Aljayyoussi
Francisco Javier Gamo
Laura Sanz
Janneth Rodrigues
Carolina Gonzalez Cortes
Esperanza Herreros
Iñigo Angulo-Barturén
María Belén Jiménez-Díaz
Santiago Ferrer Bazaga
María Santos Martínez-Martínez
Brice Campo
Raman Sharma
Eileen Ryan
David M. Shackleford
Simon Campbell
Dennis A. Smith
Grennady Wirjanata
Rintis Noviyanti
Ric N. Price
Jutta Marfurt
Michael J. Palmer
Ian M. Copple
Amy E. Mercer
Andrea Ruecker
Michael J. Delves
Robert E. Sinden
Peter Siegl
Jill Davies
Rosemary Rochford
Clemens H. M. Kocken
Anne-Marie Zeeman
Gemma L. Nixon
Giancarlo A. Biagini
Stephen A. Ward
author_sort Paul M. O’Neill
title A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
title_short A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
title_full A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
title_fullStr A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
title_full_unstemmed A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
title_sort tetraoxane-based antimalarial drug candidate that overcomes pfk13-c580y dependent artemisinin resistance
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f
work_keys_str_mv AT paulmoneill atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT richardkamewu atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT susanacharman atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT sunilsabbani atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ninafgnadig atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT judithstraimer atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT davidafidock atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT emmarshore atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT natalielroberts atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT michaelhlwong atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT wdavidhong atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT chandrakalapidathala atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT chrisriley atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT benmurphy atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ghaithaljayyoussi atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT franciscojaviergamo atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT laurasanz atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT jannethrodrigues atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT carolinagonzalezcortes atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT esperanzaherreros atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT inigoangulobarturen atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT mariabelenjimenezdiaz atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT santiagoferrerbazaga atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT mariasantosmartinezmartinez atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT bricecampo atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ramansharma atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT eileenryan atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT davidmshackleford atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT simoncampbell atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT dennisasmith atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT grennadywirjanata atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT rintisnoviyanti atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ricnprice atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT juttamarfurt atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT michaeljpalmer atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ianmcopple atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT amyemercer atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT andrearuecker atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT michaeljdelves atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT robertesinden atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT petersiegl atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT jilldavies atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT rosemaryrochford atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT clemenshmkocken atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT annemariezeeman atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT gemmalnixon atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT giancarloabiagini atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT stephenaward atetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT paulmoneill tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT richardkamewu tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT susanacharman tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT sunilsabbani tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ninafgnadig tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT judithstraimer tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT davidafidock tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT emmarshore tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT natalielroberts tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT michaelhlwong tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT wdavidhong tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT chandrakalapidathala tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT chrisriley tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT benmurphy tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ghaithaljayyoussi tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT franciscojaviergamo tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT laurasanz tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT jannethrodrigues tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT carolinagonzalezcortes tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT esperanzaherreros tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT inigoangulobarturen tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT mariabelenjimenezdiaz tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT santiagoferrerbazaga tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT mariasantosmartinezmartinez tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT bricecampo tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ramansharma tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT eileenryan tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT davidmshackleford tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT simoncampbell tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT dennisasmith tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT grennadywirjanata tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT rintisnoviyanti tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ricnprice tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT juttamarfurt tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT michaeljpalmer tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT ianmcopple tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT amyemercer tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT andrearuecker tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT michaeljdelves tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT robertesinden tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT petersiegl tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT jilldavies tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT rosemaryrochford tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT clemenshmkocken tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT annemariezeeman tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT gemmalnixon tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT giancarloabiagini tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
AT stephenaward tetraoxanebasedantimalarialdrugcandidatethatovercomespfk13c580ydependentartemisininresistance
_version_ 1718386075353743360

Ejemplares similares