Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer

Abstract We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control data from UK Biobank. Among the disease conditions studied ar...

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Autores principales: Louis Lello, Timothy G. Raben, Soke Yuen Yong, Laurent C. A. M. Tellier, Stephen D. H. Hsu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d0bbe05be1ad42e9b5b0912d11a4bc34
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