Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis

Abstract The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target to prevent fibrosis. We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a preclinical model of fibrosis. CCG-222740, a novel MRTF...

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Autores principales: Cynthia Yu-Wai-Man, Bradley Spencer-Dene, Richard M. H. Lee, Kim Hutchings, Erika M. Lisabeth, Richard Treisman, Maryse Bailly, Scott D. Larsen, Richard R. Neubig, Peng T. Khaw
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d0d09e6ee5ac462a80dbec12fafe4e2c
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