Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform

Glycine-alanine dipeptide repeats produced by the C9orf72 gene are proposed to cause neurotoxicity in related diseases, but is challenging to study experimentally. Here a photolabile cell-penetrating peptide allows superresolution imaging of the distribution and aggregation of a simple dipeptide whi...

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Autores principales:	Hung-Ming Chien, Ruei-Yu He, Chi-Chang Lee, Yung-An Huang, I-Ju Hung, Kai-Ting Hou, Jye-Chian Hsiao, Po-Chao Lu, Diksha Agnihotri, Eric Hwang, Joseph Jen-Tse Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d0d8eaa2f8954cce873fb107a77d365a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d0d8eaa2f8954cce873fb107a77d365a2021-12-02T17:03:47ZNanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform10.1038/s42004-021-00547-62399-3669https://doaj.org/article/d0d8eaa2f8954cce873fb107a77d365a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00547-6https://doaj.org/toc/2399-3669Glycine-alanine dipeptide repeats produced by the C9orf72 gene are proposed to cause neurotoxicity in related diseases, but is challenging to study experimentally. Here a photolabile cell-penetrating peptide allows superresolution imaging of the distribution and aggregation of a simple dipeptide which recapitulates neurotoxicity associated with endogenous analogues.Hung-Ming ChienRuei-Yu HeChi-Chang LeeYung-An HuangI-Ju HungKai-Ting HouJye-Chian HsiaoPo-Chao LuDiksha AgnihotriEric HwangJoseph Jen-Tse HuangNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Hung-Ming Chien Ruei-Yu He Chi-Chang Lee Yung-An Huang I-Ju Hung Kai-Ting Hou Jye-Chian Hsiao Po-Chao Lu Diksha Agnihotri Eric Hwang Joseph Jen-Tse Huang Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform
description	Glycine-alanine dipeptide repeats produced by the C9orf72 gene are proposed to cause neurotoxicity in related diseases, but is challenging to study experimentally. Here a photolabile cell-penetrating peptide allows superresolution imaging of the distribution and aggregation of a simple dipeptide which recapitulates neurotoxicity associated with endogenous analogues.
format	article
author	Hung-Ming Chien Ruei-Yu He Chi-Chang Lee Yung-An Huang I-Ju Hung Kai-Ting Hou Jye-Chian Hsiao Po-Chao Lu Diksha Agnihotri Eric Hwang Joseph Jen-Tse Huang
author_facet	Hung-Ming Chien Ruei-Yu He Chi-Chang Lee Yung-An Huang I-Ju Hung Kai-Ting Hou Jye-Chian Hsiao Po-Chao Lu Diksha Agnihotri Eric Hwang Joseph Jen-Tse Huang
author_sort	Hung-Ming Chien
title	Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform
title_short	Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform
title_full	Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform
title_fullStr	Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform
title_full_unstemmed	Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform
title_sort	nanoscopic investigation of c9orf72 poly-ga oligomers on nuclear membrane disruption by a photoinducible platform
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d0d8eaa2f8954cce873fb107a77d365a
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Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform

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