MSA: reproducible mutational signature attribution with confidence based on simulations

Abstract Background Mutational signatures proved to be a useful tool for identifying patterns of mutations in genomes, often providing valuable insights about mutagenic processes or normal DNA damage. De novo extraction of signatures is commonly performed using Non-Negative Matrix Factorisation meth...

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Autor principal: Sergey Senkin
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
MSA
Acceso en línea:https://doaj.org/article/d101f8dfde724132b54e2266d9c6cf30
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