Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation

Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation

C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML.

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Autores principales: Alexander Arthur Wurm, Polina Zjablovskaja, Miroslava Kardosova, Dennis Gerloff, Daniela Bräuer-Hartmann, Christiane Katzerke, Jens-Uwe Hartmann, Touati Benoukraf, Stephan Fricke, Nadja Hilger, Anne-Marie Müller, Marius Bill, Sebastian Schwind, Daniel G. Tenen, Dietger Niederwieser, Meritxell Alberich-Jorda, Gerhard Behre
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/d1070167e8204aeba7d47363aee0bb8f
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https://doaj.org/article/d1070167e8204aeba7d47363aee0bb8f

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