Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation
C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML.
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Nature Portfolio
2017
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oai:doaj.org-article:d1070167e8204aeba7d47363aee0bb8f2021-12-02T10:48:28ZDisruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation10.1038/s41467-017-00032-62041-1723https://doaj.org/article/d1070167e8204aeba7d47363aee0bb8f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00032-6https://doaj.org/toc/2041-1723C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML.Alexander Arthur WurmPolina ZjablovskajaMiroslava KardosovaDennis GerloffDaniela Bräuer-HartmannChristiane KatzerkeJens-Uwe HartmannTouati BenoukrafStephan FrickeNadja HilgerAnne-Marie MüllerMarius BillSebastian SchwindDaniel G. TenenDietger NiederwieserMeritxell Alberich-JordaGerhard BehreNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Alexander Arthur Wurm Polina Zjablovskaja Miroslava Kardosova Dennis Gerloff Daniela Bräuer-Hartmann Christiane Katzerke Jens-Uwe Hartmann Touati Benoukraf Stephan Fricke Nadja Hilger Anne-Marie Müller Marius Bill Sebastian Schwind Daniel G. Tenen Dietger Niederwieser Meritxell Alberich-Jorda Gerhard Behre Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation |
| description |
C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML. |
| format |
article |
| author |
Alexander Arthur Wurm Polina Zjablovskaja Miroslava Kardosova Dennis Gerloff Daniela Bräuer-Hartmann Christiane Katzerke Jens-Uwe Hartmann Touati Benoukraf Stephan Fricke Nadja Hilger Anne-Marie Müller Marius Bill Sebastian Schwind Daniel G. Tenen Dietger Niederwieser Meritxell Alberich-Jorda Gerhard Behre |
| author_facet |
Alexander Arthur Wurm Polina Zjablovskaja Miroslava Kardosova Dennis Gerloff Daniela Bräuer-Hartmann Christiane Katzerke Jens-Uwe Hartmann Touati Benoukraf Stephan Fricke Nadja Hilger Anne-Marie Müller Marius Bill Sebastian Schwind Daniel G. Tenen Dietger Niederwieser Meritxell Alberich-Jorda Gerhard Behre |
| author_sort |
Alexander Arthur Wurm |
| title |
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation |
| title_short |
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation |
| title_full |
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation |
| title_fullStr |
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation |
| title_full_unstemmed |
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation |
| title_sort |
disruption of the c/ebpα—mir-182 balance impairs granulocytic differentiation |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/d1070167e8204aeba7d47363aee0bb8f |
| work_keys_str_mv |
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| _version_ |
1718396675655991296 |