Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma

Abstract Medulloblastoma is the most common high-grade brain tumor in childhood. Medulloblastomas with c-myc amplification, classified as group 3, are the most aggressive among the four disease subtypes resulting in a 5-year overall survival of just above 50%. Despite current intensive therapy regim...

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Autores principales: Stefanie Schwinn, Zeinab Mokhtari, Sina Thusek, Theresa Schneider, Anna-Leena Sirén, Nicola Tiemeyer, Ignazio Caruana, Evelina Miele, Paul G. Schlegel, Andreas Beilhack, Matthias Wölfl
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d110698f9bd945e084481c034902c1df
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