Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1

Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1

Abstract LINC complexes are crucial for the response of muscle cell precursors to the rigidity of their environment, but the mechanisms explaining this behaviour are not known. Here we show that pathogenic mutations in LMNA or SYNE-1 responsible for severe muscle dystrophies reduced the ability of h...

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Bibliographic Details
Main Authors: Christine Schwartz, Martina Fischer, Kamel Mamchaoui, Anne Bigot, Thevy Lok, Claude Verdier, Alain Duperray, Richard Michel, Ian Holt, Thomas Voit, Suzanna Quijano-Roy, Gisèle Bonne, Catherine Coirault
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/d11533a11abc4004a70805683a076dcf
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https://doaj.org/article/d11533a11abc4004a70805683a076dcf

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