USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade

USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade

The cancer cell-extrinsic roles of deubiquitinases are unclear. Here the authors show that deubiquitinase USP12 downregulation contributes to development of an immune-suppressive tumour microenvironment in KRAS-driven lung cancers and mechanistically this is through the insufficient deubiquitination...

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Bibliographic Details
Main Authors: Zhaojuan Yang, Guiqin Xu, Boshi Wang, Yun Liu, Li Zhang, Tiantian Jing, Ming Tang, Xiaoli Xu, Kun Jiao, Lvzhu Xiang, Yujie Fu, Daoqiang Tang, Xiaoren Zhang, Weilin Jin, Guanglei Zhuang, Xiaojing Zhao, Yongzhong Liu
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/d11dd4bc56bd4a75bd7223020925e1ca
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https://doaj.org/article/d11dd4bc56bd4a75bd7223020925e1ca

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