USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade

The cancer cell-extrinsic roles of deubiquitinases are unclear. Here the authors show that deubiquitinase USP12 downregulation contributes to development of an immune-suppressive tumour microenvironment in KRAS-driven lung cancers and mechanistically this is through the insufficient deubiquitination...

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Autores principales:	Zhaojuan Yang, Guiqin Xu, Boshi Wang, Yun Liu, Li Zhang, Tiantian Jing, Ming Tang, Xiaoli Xu, Kun Jiao, Lvzhu Xiang, Yujie Fu, Daoqiang Tang, Xiaoren Zhang, Weilin Jin, Guanglei Zhuang, Xiaojing Zhao, Yongzhong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d11dd4bc56bd4a75bd7223020925e1ca
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spelling	oai:doaj.org-article:d11dd4bc56bd4a75bd7223020925e1ca2021-12-02T15:08:12ZUSP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade10.1038/s41467-021-25032-52041-1723https://doaj.org/article/d11dd4bc56bd4a75bd7223020925e1ca2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25032-5https://doaj.org/toc/2041-1723The cancer cell-extrinsic roles of deubiquitinases are unclear. Here the authors show that deubiquitinase USP12 downregulation contributes to development of an immune-suppressive tumour microenvironment in KRAS-driven lung cancers and mechanistically this is through the insufficient deubiquitination of the NF-κB inhibitor, PPM1B.Zhaojuan YangGuiqin XuBoshi WangYun LiuLi ZhangTiantian JingMing TangXiaoli XuKun JiaoLvzhu XiangYujie FuDaoqiang TangXiaoren ZhangWeilin JinGuanglei ZhuangXiaojing ZhaoYongzhong LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhaojuan Yang Guiqin Xu Boshi Wang Yun Liu Li Zhang Tiantian Jing Ming Tang Xiaoli Xu Kun Jiao Lvzhu Xiang Yujie Fu Daoqiang Tang Xiaoren Zhang Weilin Jin Guanglei Zhuang Xiaojing Zhao Yongzhong Liu USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
description	The cancer cell-extrinsic roles of deubiquitinases are unclear. Here the authors show that deubiquitinase USP12 downregulation contributes to development of an immune-suppressive tumour microenvironment in KRAS-driven lung cancers and mechanistically this is through the insufficient deubiquitination of the NF-κB inhibitor, PPM1B.
format	article
author	Zhaojuan Yang Guiqin Xu Boshi Wang Yun Liu Li Zhang Tiantian Jing Ming Tang Xiaoli Xu Kun Jiao Lvzhu Xiang Yujie Fu Daoqiang Tang Xiaoren Zhang Weilin Jin Guanglei Zhuang Xiaojing Zhao Yongzhong Liu
author_facet	Zhaojuan Yang Guiqin Xu Boshi Wang Yun Liu Li Zhang Tiantian Jing Ming Tang Xiaoli Xu Kun Jiao Lvzhu Xiang Yujie Fu Daoqiang Tang Xiaoren Zhang Weilin Jin Guanglei Zhuang Xiaojing Zhao Yongzhong Liu
author_sort	Zhaojuan Yang
title	USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
title_short	USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
title_full	USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
title_fullStr	USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
title_full_unstemmed	USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
title_sort	usp12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to pd-1 blockade
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d11dd4bc56bd4a75bd7223020925e1ca
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USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade

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