Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose that type II NKT TCRs may adapt multiple CD1d dockin...

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Autores principales:	Catarina F. Almeida, Srinivasan Sundararaj, Jérôme Le Nours, T. Praveena, Benjamin Cao, Satvika Burugupalli, Dylan G. M. Smith, Onisha Patel, Manfred Brigl, Daniel G. Pellicci, Spencer J. Williams, Adam P. Uldrich, Dale I. Godfrey, Jamie Rossjohn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1409e5d6e6042d8b4b0882766610142
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spelling	oai:doaj.org-article:d1409e5d6e6042d8b4b08827666101422021-12-02T15:36:24ZDistinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors10.1038/s41467-019-12941-92041-1723https://doaj.org/article/d1409e5d6e6042d8b4b08827666101422019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12941-9https://doaj.org/toc/2041-1723Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose that type II NKT TCRs may adapt multiple CD1d docking modes to maximise antigen recognition efficacy.Catarina F. AlmeidaSrinivasan SundararajJérôme Le NoursT. PraveenaBenjamin CaoSatvika BurugupalliDylan G. M. SmithOnisha PatelManfred BriglDaniel G. PellicciSpencer J. WilliamsAdam P. UldrichDale I. GodfreyJamie RossjohnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catarina F. Almeida Srinivasan Sundararaj Jérôme Le Nours T. Praveena Benjamin Cao Satvika Burugupalli Dylan G. M. Smith Onisha Patel Manfred Brigl Daniel G. Pellicci Spencer J. Williams Adam P. Uldrich Dale I. Godfrey Jamie Rossjohn Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
description	Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose that type II NKT TCRs may adapt multiple CD1d docking modes to maximise antigen recognition efficacy.
format	article
author	Catarina F. Almeida Srinivasan Sundararaj Jérôme Le Nours T. Praveena Benjamin Cao Satvika Burugupalli Dylan G. M. Smith Onisha Patel Manfred Brigl Daniel G. Pellicci Spencer J. Williams Adam P. Uldrich Dale I. Godfrey Jamie Rossjohn
author_facet	Catarina F. Almeida Srinivasan Sundararaj Jérôme Le Nours T. Praveena Benjamin Cao Satvika Burugupalli Dylan G. M. Smith Onisha Patel Manfred Brigl Daniel G. Pellicci Spencer J. Williams Adam P. Uldrich Dale I. Godfrey Jamie Rossjohn
author_sort	Catarina F. Almeida
title	Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
title_short	Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
title_full	Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
title_fullStr	Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
title_full_unstemmed	Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
title_sort	distinct cd1d docking strategies exhibited by diverse type ii nkt cell receptors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d1409e5d6e6042d8b4b0882766610142
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Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

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