STAT3 decoy oligonucleotide-carrying microbubbles with pulsed ultrasound for enhanced therapeutic effect in head and neck tumors.

STAT3 decoy oligonucleotide-carrying microbubbles with pulsed ultrasound for enhanced therapeutic effect in head and neck tumors.

Signal transducer and activator of transcription-3 (STAT3) is an oncogenic transcription factor implicated in carcinogenesis, tumor progression, and drug resistance in head and neck squamous cell carcinoma (HNSCC). A decoy oligonucleotide targeting STAT3 offers a promising anti-tumor strategy, but a...

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Autores principales: Thiruganesh Ramasamy, Xucai Chen, Bin Qin, Daniel E Johnson, Jennifer R Grandis, Flordeliza S Villanueva
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d15c6827cee1476b991da2a18aadc2fa
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