Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress

Endothelial dysfunction, induced by oxidative stress, is an essential factor affecting cardiovascular disease. Uncoupling of endothelial nitric oxide synthase (eNOS) leads to a decrease in nitric oxide (NO) production, an increase in reactive oxygen species (ROS) production, NO consumption, and NO s...

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Main Authors:	Peipei Meng, Rui Yang, Fenjun Jiang, Jianbo Guo, Xinyu Lu, Tao Yang, Qingyong He
Format:	article
Language:	EN
Published:	Hindawi Limited 2021
Subjects:	Cytology QH573-671
Online Access:	https://doaj.org/article/d17ae168b17d41389f66aa75dad7adec
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spelling	oai:doaj.org-article:d17ae168b17d41389f66aa75dad7adec2021-11-29T00:56:47ZMolecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress1942-099410.1155/2021/1481236https://doaj.org/article/d17ae168b17d41389f66aa75dad7adec2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1481236https://doaj.org/toc/1942-0994Endothelial dysfunction, induced by oxidative stress, is an essential factor affecting cardiovascular disease. Uncoupling of endothelial nitric oxide synthase (eNOS) leads to a decrease in nitric oxide (NO) production, an increase in reactive oxygen species (ROS) production, NO consumption, and NO synthesis. As a main active ingredient of astragalus, astragaloside IV can reduce the apoptosis of endothelial cells during oxidative stress. This review is aimed at exploring the mechanism of astragaloside IV in improving oxidative stress-mediated endothelial dysfunction relevant to cardiovascular diseases. The findings showed that the astragaloside IV can prevent or reverse the uncoupling of eNOS, increase eNOS and NO, and enhance several activating enzymes to activate the antioxidant system. In-depth validation and quantitative experiments still need to be implemented.Peipei MengRui YangFenjun JiangJianbo GuoXinyu LuTao YangQingyong HeHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Peipei Meng Rui Yang Fenjun Jiang Jianbo Guo Xinyu Lu Tao Yang Qingyong He Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
description	Endothelial dysfunction, induced by oxidative stress, is an essential factor affecting cardiovascular disease. Uncoupling of endothelial nitric oxide synthase (eNOS) leads to a decrease in nitric oxide (NO) production, an increase in reactive oxygen species (ROS) production, NO consumption, and NO synthesis. As a main active ingredient of astragalus, astragaloside IV can reduce the apoptosis of endothelial cells during oxidative stress. This review is aimed at exploring the mechanism of astragaloside IV in improving oxidative stress-mediated endothelial dysfunction relevant to cardiovascular diseases. The findings showed that the astragaloside IV can prevent or reverse the uncoupling of eNOS, increase eNOS and NO, and enhance several activating enzymes to activate the antioxidant system. In-depth validation and quantitative experiments still need to be implemented.
format	article
author	Peipei Meng Rui Yang Fenjun Jiang Jianbo Guo Xinyu Lu Tao Yang Qingyong He
author_facet	Peipei Meng Rui Yang Fenjun Jiang Jianbo Guo Xinyu Lu Tao Yang Qingyong He
author_sort	Peipei Meng
title	Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_short	Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_full	Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_fullStr	Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_full_unstemmed	Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_sort	molecular mechanism of astragaloside iv in improving endothelial dysfunction of cardiovascular diseases mediated by oxidative stress
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d17ae168b17d41389f66aa75dad7adec
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Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress

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