Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesis of further new cytotoxic protoflavone derivatives.

Protoapigenone, a natural flavonoid possessing an unusual p-quinol moiety on its B-ring, is a novel prospective anticancer agent with low toxicity that is currently in development. The first economical, one-step synthesis of protoapigenone from apigenin is described on up to gram scale. 13 new 1...

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Autores principales: Attila Hunyadi, Da-Wei Chuang, Balazs Danko, Michael Y Chiang, Chia-Lin Lee, Hui-Chun Wang, Chin-Chung Wu, Fang-Rong Chang, Yang-Chang Wu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/d188a385df8945ed8271391f3925f08f
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