Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25

Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicited in human immunoglobulin loci transgenic mice.

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Autores principales:	Stephen W. Scally, Brandon McLeod, Alexandre Bosch, Kazutoyo Miura, Qi Liang, Sean Carroll, Sini Reponen, Ngan Nguyen, Eldar Giladi, Sebastian Rämisch, Vidadi Yusibov, Allan Bradley, Franck Lemiale, William R. Schief, Daniel Emerling, Paul Kellam, C. Richter King, Jean-Philippe Julien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1902f6099734fd8a2c75117c776ee4d
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spelling	oai:doaj.org-article:d1902f6099734fd8a2c75117c776ee4d2021-12-02T17:06:05ZMolecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs2510.1038/s41467-017-01924-32041-1723https://doaj.org/article/d1902f6099734fd8a2c75117c776ee4d2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01924-3https://doaj.org/toc/2041-1723Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicited in human immunoglobulin loci transgenic mice.Stephen W. ScallyBrandon McLeodAlexandre BoschKazutoyo MiuraQi LiangSean CarrollSini ReponenNgan NguyenEldar GiladiSebastian RämischVidadi YusibovAllan BradleyFranck LemialeWilliam R. SchiefDaniel EmerlingPaul KellamC. Richter KingJean-Philippe JulienNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen W. Scally Brandon McLeod Alexandre Bosch Kazutoyo Miura Qi Liang Sean Carroll Sini Reponen Ngan Nguyen Eldar Giladi Sebastian Rämisch Vidadi Yusibov Allan Bradley Franck Lemiale William R. Schief Daniel Emerling Paul Kellam C. Richter King Jean-Philippe Julien Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
description	Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicited in human immunoglobulin loci transgenic mice.
format	article
author	Stephen W. Scally Brandon McLeod Alexandre Bosch Kazutoyo Miura Qi Liang Sean Carroll Sini Reponen Ngan Nguyen Eldar Giladi Sebastian Rämisch Vidadi Yusibov Allan Bradley Franck Lemiale William R. Schief Daniel Emerling Paul Kellam C. Richter King Jean-Philippe Julien
author_facet	Stephen W. Scally Brandon McLeod Alexandre Bosch Kazutoyo Miura Qi Liang Sean Carroll Sini Reponen Ngan Nguyen Eldar Giladi Sebastian Rämisch Vidadi Yusibov Allan Bradley Franck Lemiale William R. Schief Daniel Emerling Paul Kellam C. Richter King Jean-Philippe Julien
author_sort	Stephen W. Scally
title	Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
title_short	Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
title_full	Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
title_fullStr	Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
title_full_unstemmed	Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
title_sort	molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen pfs25
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d1902f6099734fd8a2c75117c776ee4d
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Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25

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