Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation

Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation

ABSTRACT Late in the HIV-1 replication cycle, the viral structural protein Gag is targeted to virus assembly sites at the plasma membrane of infected cells. The capsid (CA) domain of Gag plays a critical role in the formation of the hexameric Gag lattice in the immature virion, and, during particle...

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Main Authors: Mariia Novikova, Lucas J. Adams, Juan Fontana, Anna T. Gres, Muthukumar Balasubramaniam, Dennis C. Winkler, Sagar B. Kudchodkar, Ferri Soheilian, Stefan G. Sarafianos, Alasdair C. Steven, Eric O. Freed
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
Cryo-EM
HIV-1
assembly
capsid
maturation
virus replication
Microbiology
QR1-502
Online Access:https://doaj.org/article/d1bc164630d541f6abb520b9b82a3d58
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https://doaj.org/article/d1bc164630d541f6abb520b9b82a3d58

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