YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions.

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Bibliographic Details
Main Authors:	Yulin Shi, Songqing Fan, Mengge Wu, Zhixiang Zuo, Xingyang Li, Liping Jiang, Qiushuo Shen, Peifang Xu, Lin Zeng, Yongchun Zhou, Yunchao Huang, Zuozhang Yang, Jumin Zhou, Jing Gao, Hu Zhou, Shuhua Xu, Hongbin Ji, Peng Shi, Dong-Dong Wu, Cuiping Yang, Yongbin Chen
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/d1c5532fac1b4a15a88397d24a21c802
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spelling	oai:doaj.org-article:d1c5532fac1b4a15a88397d24a21c8022021-12-02T17:01:31ZYTHDF1 links hypoxia adaptation and non-small cell lung cancer progression10.1038/s41467-019-12801-62041-1723https://doaj.org/article/d1c5532fac1b4a15a88397d24a21c8022019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12801-6https://doaj.org/toc/2041-1723Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions.Yulin ShiSongqing FanMengge WuZhixiang ZuoXingyang LiLiping JiangQiushuo ShenPeifang XuLin ZengYongchun ZhouYunchao HuangZuozhang YangJumin ZhouJing GaoHu ZhouShuhua XuHongbin JiPeng ShiDong-Dong WuCuiping YangYongbin ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yulin Shi Songqing Fan Mengge Wu Zhixiang Zuo Xingyang Li Liping Jiang Qiushuo Shen Peifang Xu Lin Zeng Yongchun Zhou Yunchao Huang Zuozhang Yang Jumin Zhou Jing Gao Hu Zhou Shuhua Xu Hongbin Ji Peng Shi Dong-Dong Wu Cuiping Yang Yongbin Chen YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
description	Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions.
format	article
author	Yulin Shi Songqing Fan Mengge Wu Zhixiang Zuo Xingyang Li Liping Jiang Qiushuo Shen Peifang Xu Lin Zeng Yongchun Zhou Yunchao Huang Zuozhang Yang Jumin Zhou Jing Gao Hu Zhou Shuhua Xu Hongbin Ji Peng Shi Dong-Dong Wu Cuiping Yang Yongbin Chen
author_facet	Yulin Shi Songqing Fan Mengge Wu Zhixiang Zuo Xingyang Li Liping Jiang Qiushuo Shen Peifang Xu Lin Zeng Yongchun Zhou Yunchao Huang Zuozhang Yang Jumin Zhou Jing Gao Hu Zhou Shuhua Xu Hongbin Ji Peng Shi Dong-Dong Wu Cuiping Yang Yongbin Chen
author_sort	Yulin Shi
title	YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
title_short	YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
title_full	YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
title_fullStr	YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
title_full_unstemmed	YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
title_sort	ythdf1 links hypoxia adaptation and non-small cell lung cancer progression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d1c5532fac1b4a15a88397d24a21c802
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YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

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