A proximity proteomics screen in three-dimensional spheroid cultures identifies novel regulators of lumen formation

Abstract Apical-basal cell polarity and lumen formation are essential features of many epithelial tissues, which are disrupted in diseases like cancer. Here, we describe a proteomics-based screen to identify proteins involved in lumen formation in three-dimensional spheroid cultures. We established...

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Autores principales: Li-Ting Wang, Marie-Ève Proulx, Anne D. Kim, Virginie Lelarge, Luke McCaffrey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d1c642ffdd794441a5399ca63e0419b8
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