Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells

Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells

Abstract Background Redirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is attractive in developing off-the-shelf CAR therapeutics for cancer treatment. However, the site-specific integration of a CAR gene into NK cells remains challenging. Methods In the present study, we...

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Autores principales: Shin Yi Tang, Shijun Zha, Zhicheng Du, Jieming Zeng, Detu Zhu, Yumei Luo, Shu Wang
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Induced pluripotent stem cells (iPSC)
Natural killer cells (NK)
Chimeric antigen receptors (CAR)
Adeno-associated virus integration site 1 (AAVS1)
Zinc finger nuclease (ZFN)
Genetic engineering
Medicine (General)
R5-920
Biochemistry
QD415-436
Acceso en línea:https://doaj.org/article/d1ce988184354b54b4107b2f9529c336
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https://doaj.org/article/d1ce988184354b54b4107b2f9529c336

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