Structural basis for two-way communication between dynein and microtubules

The movement of cytoplasmic dynein on microtubule tracks is coordinated by the microtubule-binding domain (MTBD) and the ATPase domain via a coiled-coil stalk. Here authors use NMR and cryo-EM and suggest that the communication between the ATPase-domain and MTBD is achieved by sliding of the stalk α...

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Autores principales: Noritaka Nishida, Yuta Komori, Osamu Takarada, Atsushi Watanabe, Satoko Tamura, Satoshi Kubo, Ichio Shimada, Masahide Kikkawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d1ea81cf3f6d4a4f9f1f0bbb49e57455
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