Tau Regulates Glioblastoma Progression, 3D Cell Organization, Growth and Migration via the PI3K-AKT Axis

Tau Regulates Glioblastoma Progression, 3D Cell Organization, Growth and Migration via the PI3K-AKT Axis

The Microtubule-Associated Protein Tau is expressed in several cancers, including low-grade gliomas and glioblastomas. We have previously shown that Tau is crucial for the 2D motility of several glioblastoma cell lines, including U87-MG cells. Using an RNA interference (shRNA), we tested if Tau cont...

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Detalles Bibliográficos
Autores principales: Alessandra Pagano, Gilles Breuzard, Fabrice Parat, Aurélie Tchoghandjian, Dominique Figarella-Branger, Tiphany Coralie De Bessa, Françoise Garrouste, Alexis Douence, Pascale Barbier, Hervé Kovacic
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
Microtubule-Associated Protein Tau (MAPT)
glioblastoma
N-cadherin
PI3 kinase (PI3K)
Akt
multicellular spheroid
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/d1ee2278df8c4deeb69fd6b8526bc7af
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https://doaj.org/article/d1ee2278df8c4deeb69fd6b8526bc7af

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