Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro

Backbone extended monomers are poorly compatible with the natural ribosomes, impeding their polymerization into polypeptides. Here the authors design non-canonical amino acid analogs with cyclic structures or extended carbon chains and used an engineered ribosome to improve tRNA-charging and incorpo...

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Autores principales:	Joongoo Lee, Kevin J. Schwarz, Do Soon Kim, Jeffrey S. Moore, Michael C. Jewett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1f0310e1e4a4c63ab01552ba5fb1c77
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spelling	oai:doaj.org-article:d1f0310e1e4a4c63ab01552ba5fb1c772021-12-02T15:09:25ZRibosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro10.1038/s41467-020-18001-x2041-1723https://doaj.org/article/d1f0310e1e4a4c63ab01552ba5fb1c772020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18001-xhttps://doaj.org/toc/2041-1723Backbone extended monomers are poorly compatible with the natural ribosomes, impeding their polymerization into polypeptides. Here the authors design non-canonical amino acid analogs with cyclic structures or extended carbon chains and used an engineered ribosome to improve tRNA-charging and incorporation into peptides.Joongoo LeeKevin J. SchwarzDo Soon KimJeffrey S. MooreMichael C. JewettNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joongoo Lee Kevin J. Schwarz Do Soon Kim Jeffrey S. Moore Michael C. Jewett Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
description	Backbone extended monomers are poorly compatible with the natural ribosomes, impeding their polymerization into polypeptides. Here the authors design non-canonical amino acid analogs with cyclic structures or extended carbon chains and used an engineered ribosome to improve tRNA-charging and incorporation into peptides.
format	article
author	Joongoo Lee Kevin J. Schwarz Do Soon Kim Jeffrey S. Moore Michael C. Jewett
author_facet	Joongoo Lee Kevin J. Schwarz Do Soon Kim Jeffrey S. Moore Michael C. Jewett
author_sort	Joongoo Lee
title	Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
title_short	Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
title_full	Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
title_fullStr	Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
title_full_unstemmed	Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
title_sort	ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d1f0310e1e4a4c63ab01552ba5fb1c77
work_keys_str_mv	AT joongoolee ribosomemediatedpolymerizationoflongchaincarbonandcyclicaminoacidsintopeptidesinvitro AT kevinjschwarz ribosomemediatedpolymerizationoflongchaincarbonandcyclicaminoacidsintopeptidesinvitro AT dosoonkim ribosomemediatedpolymerizationoflongchaincarbonandcyclicaminoacidsintopeptidesinvitro AT jeffreysmoore ribosomemediatedpolymerizationoflongchaincarbonandcyclicaminoacidsintopeptidesinvitro AT michaelcjewett ribosomemediatedpolymerizationoflongchaincarbonandcyclicaminoacidsintopeptidesinvitro
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Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro

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