Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications

N-acetyl-muramic acid (NAM) is a core component of the bacterial peptidoglycan (PG) cell wall, and is recognised by the innate immune system. Here the authors engineer Gram-negative and Gram-positive bacteria to incorporate a modified NAM into the backbone of PG, which can be labelled with click che...

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Autores principales:	Hai Liang, Kristen E. DeMeester, Ching-Wen Hou, Michelle A. Parent, Jeffrey L. Caplan, Catherine L. Grimes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2137f58154341eaa6ef192a234541b0
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spelling	oai:doaj.org-article:d2137f58154341eaa6ef192a234541b02021-12-02T15:38:35ZMetabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications10.1038/ncomms150152041-1723https://doaj.org/article/d2137f58154341eaa6ef192a234541b02017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15015https://doaj.org/toc/2041-1723N-acetyl-muramic acid (NAM) is a core component of the bacterial peptidoglycan (PG) cell wall, and is recognised by the innate immune system. Here the authors engineer Gram-negative and Gram-positive bacteria to incorporate a modified NAM into the backbone of PG, which can be labelled with click chemistry for imaging and tracking.Hai LiangKristen E. DeMeesterChing-Wen HouMichelle A. ParentJeffrey L. CaplanCatherine L. GrimesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hai Liang Kristen E. DeMeester Ching-Wen Hou Michelle A. Parent Jeffrey L. Caplan Catherine L. Grimes Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications
description	N-acetyl-muramic acid (NAM) is a core component of the bacterial peptidoglycan (PG) cell wall, and is recognised by the innate immune system. Here the authors engineer Gram-negative and Gram-positive bacteria to incorporate a modified NAM into the backbone of PG, which can be labelled with click chemistry for imaging and tracking.
format	article
author	Hai Liang Kristen E. DeMeester Ching-Wen Hou Michelle A. Parent Jeffrey L. Caplan Catherine L. Grimes
author_facet	Hai Liang Kristen E. DeMeester Ching-Wen Hou Michelle A. Parent Jeffrey L. Caplan Catherine L. Grimes
author_sort	Hai Liang
title	Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications
title_short	Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications
title_full	Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications
title_fullStr	Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications
title_full_unstemmed	Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications
title_sort	metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d2137f58154341eaa6ef192a234541b0
work_keys_str_mv	AT hailiang metaboliclabellingofthecarbohydratecoreinbacterialpeptidoglycananditsapplications AT kristenedemeester metaboliclabellingofthecarbohydratecoreinbacterialpeptidoglycananditsapplications AT chingwenhou metaboliclabellingofthecarbohydratecoreinbacterialpeptidoglycananditsapplications AT michelleaparent metaboliclabellingofthecarbohydratecoreinbacterialpeptidoglycananditsapplications AT jeffreylcaplan metaboliclabellingofthecarbohydratecoreinbacterialpeptidoglycananditsapplications AT catherinelgrimes metaboliclabellingofthecarbohydratecoreinbacterialpeptidoglycananditsapplications
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Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications

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