Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.

We have previously shown that soluble collagen and a human pathogen, echovirus 1 (EV1) cluster α2β1 integrin on the plasma membrane and cause their internalization into cytoplasmic endosomes. Here we show that cholesterol plays a major role not only in the uptake of α2β1 integrin and its ligands but...

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Autores principales: Elina Siljamäki, Nina Rintanen, Maija Kirsi, Paula Upla, Wei Wang, Mikko Karjalainen, Elina Ikonen, Varpu Marjomäki
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/d2195a4d8bbb42d4a6856e89dbaa4b6b
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