The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus

The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus

Type 1 diabetes mellitus (DM1) is associated with compromised (defective) immunologic tolerance to autoantigens and selective destruction of pancreatic B-cells by CD4+ (effector) and CD8 (cytotoxic) lymphocytes. The mechanisms of autotolerance involve CD4+CD25+high T-regulatory cells (Treg) whose su...

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Main Authors: Tatiana Vasil'evna Nikonova, Pavel Vasil'evich Apanovich, Elena Vladimirovna Pekareva, Vera Anatol'evna Gorelysheva, Sergey Alexandrovich Prokof'ev, Alexander Vasil'evich Karpukhin, Ivan Ivanovich Dedov
Format: article
Language:EN
RU
Published: Endocrinology Research Centre 2010
Subjects:
type 1 diabetes mellitus
subjects at risk if dm1
cd4+cd25+high regulatory t-lymphocytes
foxp3 gene
Nutritional diseases. Deficiency diseases
RC620-627
Online Access:https://doaj.org/article/d25393636268490b95fce9d3182b0abb
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https://doaj.org/article/d25393636268490b95fce9d3182b0abb

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