The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus

Type 1 diabetes mellitus (DM1) is associated with compromised (defective) immunologic tolerance to autoantigens and selective destruction of pancreatic B-cells by CD4+ (effector) and CD8 (cytotoxic) lymphocytes. The mechanisms of autotolerance involve CD4+CD25+high T-regulatory cells (Treg) whose su...

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Autores principales:	Tatiana Vasil'evna Nikonova, Pavel Vasil'evich Apanovich, Elena Vladimirovna Pekareva, Vera Anatol'evna Gorelysheva, Sergey Alexandrovich Prokof'ev, Alexander Vasil'evich Karpukhin, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2010
Materias:	type 1 diabetes mellitus subjects at risk if dm1 cd4+cd25+high regulatory t-lymphocytes foxp3 gene Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/d25393636268490b95fce9d3182b0abb
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spelling	oai:doaj.org-article:d25393636268490b95fce9d3182b0abb2021-11-14T09:00:15ZThe role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus2072-03512072-037810.14341/2072-0351-5483https://doaj.org/article/d25393636268490b95fce9d3182b0abb2010-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5483https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Type 1 diabetes mellitus (DM1) is associated with compromised (defective) immunologic tolerance to autoantigens and selective destruction of pancreatic B-cells by CD4+ (effector) and CD8 (cytotoxic) lymphocytes. The mechanisms of autotolerance involve CD4+CD25+high T-regulatory cells (Treg) whose suppressor activity depends on the expression of the FoxP3 gene. Aim. Detection of quantitative and functional alterations at the level of regulation of immunity in subjects at risk of DM1 and patients with different duration of DM1. Materials and methods. 116 patients (67 men and 49 women) with different duration of DM1. The risk group was comprised of 33 subjects (10 men and 23 women), control group included 16 subjects. In all cases, HLA genotyping was performed, autoantibodies to GDC, insulin and tyrosine phosphatase, islet cell antigens were determined, subpopulation composition of CD3+, CD4+, CD8+, CD38+, HLA DR+, CD25+, CD4+25+ lymphocytes and their functional activities (FoxP3 gene expression) studied, C-peptie and HbA1c levels measured. Results. A tendency toward a rise in Cd25+ and CD4+25+ T-lymphocytes and a decrease in FoxP3 expression was documented in the risk group compared with control (p0.05) but their functional activity was lower (pTatiana Vasil'evna NikonovaPavel Vasil'evich ApanovichElena Vladimirovna PekarevaVera Anatol'evna GorelyshevaSergey Alexandrovich Prokof'evAlexander Vasil'evich KarpukhinIvan Ivanovich DedovEndocrinology Research Centrearticletype 1 diabetes mellitussubjects at risk if dm1cd4+cd25+high regulatory t-lymphocytesfoxp3 geneNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 3, Pp 25-31 (2010)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus subjects at risk if dm1 cd4+cd25+high regulatory t-lymphocytes foxp3 gene Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus subjects at risk if dm1 cd4+cd25+high regulatory t-lymphocytes foxp3 gene Nutritional diseases. Deficiency diseases RC620-627 Tatiana Vasil'evna Nikonova Pavel Vasil'evich Apanovich Elena Vladimirovna Pekareva Vera Anatol'evna Gorelysheva Sergey Alexandrovich Prokof'ev Alexander Vasil'evich Karpukhin Ivan Ivanovich Dedov The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus
description	Type 1 diabetes mellitus (DM1) is associated with compromised (defective) immunologic tolerance to autoantigens and selective destruction of pancreatic B-cells by CD4+ (effector) and CD8 (cytotoxic) lymphocytes. The mechanisms of autotolerance involve CD4+CD25+high T-regulatory cells (Treg) whose suppressor activity depends on the expression of the FoxP3 gene. Aim. Detection of quantitative and functional alterations at the level of regulation of immunity in subjects at risk of DM1 and patients with different duration of DM1. Materials and methods. 116 patients (67 men and 49 women) with different duration of DM1. The risk group was comprised of 33 subjects (10 men and 23 women), control group included 16 subjects. In all cases, HLA genotyping was performed, autoantibodies to GDC, insulin and tyrosine phosphatase, islet cell antigens were determined, subpopulation composition of CD3+, CD4+, CD8+, CD38+, HLA DR+, CD25+, CD4+25+ lymphocytes and their functional activities (FoxP3 gene expression) studied, C-peptie and HbA1c levels measured. Results. A tendency toward a rise in Cd25+ and CD4+25+ T-lymphocytes and a decrease in FoxP3 expression was documented in the risk group compared with control (p0.05) but their functional activity was lower (p
format	article
author	Tatiana Vasil'evna Nikonova Pavel Vasil'evich Apanovich Elena Vladimirovna Pekareva Vera Anatol'evna Gorelysheva Sergey Alexandrovich Prokof'ev Alexander Vasil'evich Karpukhin Ivan Ivanovich Dedov
author_facet	Tatiana Vasil'evna Nikonova Pavel Vasil'evich Apanovich Elena Vladimirovna Pekareva Vera Anatol'evna Gorelysheva Sergey Alexandrovich Prokof'ev Alexander Vasil'evich Karpukhin Ivan Ivanovich Dedov
author_sort	Tatiana Vasil'evna Nikonova
title	The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus
title_short	The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus
title_full	The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus
title_fullStr	The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus
title_full_unstemmed	The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus
title_sort	role of regulatory cd4+cd25+high t-lymphocytes and their functional activity in the development of type 1 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2010
url	https://doaj.org/article/d25393636268490b95fce9d3182b0abb
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The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus

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