Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis
Increasingly large scRNA-seq datasets demand better and more scalable analysis tools. Here, the authors introduce a scalable unsupervised deep embedding algorithm that clusters scRNA-seq data by iteratively optimizing a clustering objective function and enables removal of batch effects.
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Main Authors: | Xiangjie Li, Kui Wang, Yafei Lyu, Huize Pan, Jingxiao Zhang, Dwight Stambolian, Katalin Susztak, Muredach P. Reilly, Gang Hu, Mingyao Li |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
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Subjects: | |
Online Access: | https://doaj.org/article/d25ce1857e63443bb60277874e79ad11 |
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