Size and Structure of Empty and Filled Nanocontainer Based on Peptide Dendrimer with Histidine Spacers at Different pH

Size and Structure of Empty and Filled Nanocontainer Based on Peptide Dendrimer with Histidine Spacers at Different pH

Novel peptide dendrimer with Lys-2His repeating units was recently synthesized, studied by NMR (Molecules, 2019, 24, 2481) and tested as a nanocontainer for siRNA delivery (Int. J. Mol. Sci., 2020, 21, 3138). Histidine amino acid residues were inserted in the spacers of this dendrimer. Increase of t...

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Bibliographic Details
Main Authors: Valeriy V. Bezrodnyi, Sofia E. Mikhtaniuk, Oleg V. Shavykin, Igor M. Neelov, Nadezhda N. Sheveleva, Denis A. Markelov
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
peptide dendrimer
pH responsive spacers
molecular dynamics simulation
histidine–histidine pairing
nanocontainer capacity
Organic chemistry
QD241-441
Online Access:https://doaj.org/article/d29294a8a720488abdfb868356fcb48f
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https://doaj.org/article/d29294a8a720488abdfb868356fcb48f

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