A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

Mutations that lead to misfolding of rhodopsin can cause retinitis pigmentosa. Here, the authors carry out a high throughput screen to identify a small molecule chaperone of rod opsin, and show that it protects mouse models of retinitis pigmentosa from retinal degeneration.

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Detalles Bibliográficos
Autores principales: Yuanyuan Chen, Yu Chen, Beata Jastrzebska, Marcin Golczak, Sahil Gulati, Hong Tang, William Seibel, Xiaoyu Li, Hui Jin, Yong Han, Songqi Gao, Jianye Zhang, Xujie Liu, Hossein Heidari-Torkabadi, Phoebe L. Stewart, William E. Harte, Gregory P. Tochtrop, Krzysztof Palczewski
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/d2d584c977cb4762bef27d1675ed8e92
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https://doaj.org/article/d2d584c977cb4762bef27d1675ed8e92

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