A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

Mutations that lead to misfolding of rhodopsin can cause retinitis pigmentosa. Here, the authors carry out a high throughput screen to identify a small molecule chaperone of rod opsin, and show that it protects mouse models of retinitis pigmentosa from retinal degeneration.

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Autores principales:	Yuanyuan Chen, Yu Chen, Beata Jastrzebska, Marcin Golczak, Sahil Gulati, Hong Tang, William Seibel, Xiaoyu Li, Hui Jin, Yong Han, Songqi Gao, Jianye Zhang, Xujie Liu, Hossein Heidari-Torkabadi, Phoebe L. Stewart, William E. Harte, Gregory P. Tochtrop, Krzysztof Palczewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2d584c977cb4762bef27d1675ed8e92
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spelling	oai:doaj.org-article:d2d584c977cb4762bef27d1675ed8e922021-12-02T16:49:24ZA novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration10.1038/s41467-018-04261-12041-1723https://doaj.org/article/d2d584c977cb4762bef27d1675ed8e922018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04261-1https://doaj.org/toc/2041-1723Mutations that lead to misfolding of rhodopsin can cause retinitis pigmentosa. Here, the authors carry out a high throughput screen to identify a small molecule chaperone of rod opsin, and show that it protects mouse models of retinitis pigmentosa from retinal degeneration.Yuanyuan ChenYu ChenBeata JastrzebskaMarcin GolczakSahil GulatiHong TangWilliam SeibelXiaoyu LiHui JinYong HanSongqi GaoJianye ZhangXujie LiuHossein Heidari-TorkabadiPhoebe L. StewartWilliam E. HarteGregory P. TochtropKrzysztof PalczewskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanyuan Chen Yu Chen Beata Jastrzebska Marcin Golczak Sahil Gulati Hong Tang William Seibel Xiaoyu Li Hui Jin Yong Han Songqi Gao Jianye Zhang Xujie Liu Hossein Heidari-Torkabadi Phoebe L. Stewart William E. Harte Gregory P. Tochtrop Krzysztof Palczewski A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
description	Mutations that lead to misfolding of rhodopsin can cause retinitis pigmentosa. Here, the authors carry out a high throughput screen to identify a small molecule chaperone of rod opsin, and show that it protects mouse models of retinitis pigmentosa from retinal degeneration.
format	article
author	Yuanyuan Chen Yu Chen Beata Jastrzebska Marcin Golczak Sahil Gulati Hong Tang William Seibel Xiaoyu Li Hui Jin Yong Han Songqi Gao Jianye Zhang Xujie Liu Hossein Heidari-Torkabadi Phoebe L. Stewart William E. Harte Gregory P. Tochtrop Krzysztof Palczewski
author_facet	Yuanyuan Chen Yu Chen Beata Jastrzebska Marcin Golczak Sahil Gulati Hong Tang William Seibel Xiaoyu Li Hui Jin Yong Han Songqi Gao Jianye Zhang Xujie Liu Hossein Heidari-Torkabadi Phoebe L. Stewart William E. Harte Gregory P. Tochtrop Krzysztof Palczewski
author_sort	Yuanyuan Chen
title	A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
title_short	A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
title_full	A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
title_fullStr	A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
title_full_unstemmed	A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
title_sort	novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d2d584c977cb4762bef27d1675ed8e92
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A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

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