Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo.
<h4>Purpose</h4>To test the hypothesis that imaging biomarkers are useful for evaluating in vivo rod photoreceptor cell responses to a mitochondrial protonophore.<h4>Methods</h4>Intraperitoneal injections of either the mitochondrial uncoupler 2,4 dinitrophenol (DNP) or saline...
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Auteurs principaux: | Bruce A Berkowitz, Hailey K Olds, Collin Richards, Joydip Joy, Tilman Rosales, Robert H Podolsky, Karen Lins Childers, W Brad Hubbard, Patrick G Sullivan, Shasha Gao, Yichao Li, Haohua Qian, Robin Roberts |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2020
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Accès en ligne: | https://doaj.org/article/d2e55ae9cde34035a82fb7d7686e1036 |
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