Directed evolution for high functional production and stability of a challenging G protein-coupled receptor

Directed evolution for high functional production and stability of a challenging G protein-coupled receptor

Abstract Membrane proteins such as G protein-coupled receptors (GPCRs) carry out many fundamental biological functions, are involved in a large number of physiological responses, and are thus important drug targets. To allow detailed biophysical and structural studies, most of these important recept...

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Autores principales: Yann Waltenspühl, Jeliazko R. Jeliazkov, Lutz Kummer, Andreas Plückthun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d30d7a1ad5c34e6caa1d47c532bf4b8b
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