Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neu...

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Main Authors: Bart C. Jongbloets, Suzanne Lemstra, Roberta Schellino, Mark H. Broekhoven, Jyoti Parkash, Anita J. C. G. M. Hellemons, Tianyi Mao, Paolo Giacobini, Henriette van Praag, Silvia De Marchis, Geert M. J. Ramakers, R. Jeroen Pasterkamp
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/d30daa3df5364f93beb8a981d0a1cc8e
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