A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional target of YAP/TAZ, thus providing a feed forward l...

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Autores principales:	Mandeep K. Gill, Tania Christova, Ying Y. Zhang, Alex Gregorieff, Liang Zhang, Masahiro Narimatsu, Siyuan Song, Shawn Xiong, Amber L. Couzens, Jiefei Tong, Jonathan R. Krieger, Michael F. Moran, Alexandre R. Zlotta, Theodorus H. van der Kwast, Anne-Claude Gingras, Frank Sicheri, Jeffrey L. Wrana, Liliana Attisano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d30df4cc14bf4f8f98f52cdb55527dcc
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spelling	oai:doaj.org-article:d30df4cc14bf4f8f98f52cdb55527dcc2021-12-02T14:40:06ZA feed forward loop enforces YAP/TAZ signaling during tumorigenesis10.1038/s41467-018-05939-22041-1723https://doaj.org/article/d30df4cc14bf4f8f98f52cdb55527dcc2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05939-2https://doaj.org/toc/2041-1723The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional target of YAP/TAZ, thus providing a feed forward loop to promote tumorigenesis.Mandeep K. GillTania ChristovaYing Y. ZhangAlex GregorieffLiang ZhangMasahiro NarimatsuSiyuan SongShawn XiongAmber L. CouzensJiefei TongJonathan R. KriegerMichael F. MoranAlexandre R. ZlottaTheodorus H. van der KwastAnne-Claude GingrasFrank SicheriJeffrey L. WranaLiliana AttisanoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mandeep K. Gill Tania Christova Ying Y. Zhang Alex Gregorieff Liang Zhang Masahiro Narimatsu Siyuan Song Shawn Xiong Amber L. Couzens Jiefei Tong Jonathan R. Krieger Michael F. Moran Alexandre R. Zlotta Theodorus H. van der Kwast Anne-Claude Gingras Frank Sicheri Jeffrey L. Wrana Liliana Attisano A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
description	The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional target of YAP/TAZ, thus providing a feed forward loop to promote tumorigenesis.
format	article
author	Mandeep K. Gill Tania Christova Ying Y. Zhang Alex Gregorieff Liang Zhang Masahiro Narimatsu Siyuan Song Shawn Xiong Amber L. Couzens Jiefei Tong Jonathan R. Krieger Michael F. Moran Alexandre R. Zlotta Theodorus H. van der Kwast Anne-Claude Gingras Frank Sicheri Jeffrey L. Wrana Liliana Attisano
author_facet	Mandeep K. Gill Tania Christova Ying Y. Zhang Alex Gregorieff Liang Zhang Masahiro Narimatsu Siyuan Song Shawn Xiong Amber L. Couzens Jiefei Tong Jonathan R. Krieger Michael F. Moran Alexandre R. Zlotta Theodorus H. van der Kwast Anne-Claude Gingras Frank Sicheri Jeffrey L. Wrana Liliana Attisano
author_sort	Mandeep K. Gill
title	A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
title_short	A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
title_full	A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
title_fullStr	A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
title_full_unstemmed	A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
title_sort	feed forward loop enforces yap/taz signaling during tumorigenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d30df4cc14bf4f8f98f52cdb55527dcc
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A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

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