An expanded library of orthogonal split inteins enables modular multi-peptide assemblies

Inteins allow the joining of protein segments through scarless ligation. Here the authors assess 34 inteins to establish a library of 15 mutually orthogonal split inteins for in vivo applications, 10 of which are also active in vitro.

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Detalles Bibliográficos
Autores principales: Filipe Pinto, Ella Lucille Thornton, Baojun Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/d32db6de3fea472f85940d2aac88783f
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