Tumor-reprogrammed resident T cells resist radiation to control tumors

Lymphocytes are considered one of the most radiosensitive cell types in the body. Here the authors show that unlike circulating lymphocytes, tumor-infiltrating T cells survive therapeutic doses of irradiation, remaining functional and contributing to radiotherapy induced anti-tumor immunity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ainhoa Arina, Michael Beckett, Christian Fernandez, Wenxin Zheng, Sean Pitroda, Steven J. Chmura, Jason J. Luke, Martin Forde, Yuzhu Hou, Byron Burnette, Helena Mauceri, Israel Lowy, Tasha Sims, Nikolai Khodarev, Yang-Xin Fu, Ralph R. Weichselbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d33bd7c45d314883a3946267882043c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d33bd7c45d314883a3946267882043c5
record_format	dspace
spelling	oai:doaj.org-article:d33bd7c45d314883a3946267882043c52021-12-02T14:40:19ZTumor-reprogrammed resident T cells resist radiation to control tumors10.1038/s41467-019-11906-22041-1723https://doaj.org/article/d33bd7c45d314883a3946267882043c52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11906-2https://doaj.org/toc/2041-1723Lymphocytes are considered one of the most radiosensitive cell types in the body. Here the authors show that unlike circulating lymphocytes, tumor-infiltrating T cells survive therapeutic doses of irradiation, remaining functional and contributing to radiotherapy induced anti-tumor immunity.Ainhoa ArinaMichael BeckettChristian FernandezWenxin ZhengSean PitrodaSteven J. ChmuraJason J. LukeMartin FordeYuzhu HouByron BurnetteHelena MauceriIsrael LowyTasha SimsNikolai KhodarevYang-Xin FuRalph R. WeichselbaumNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ainhoa Arina Michael Beckett Christian Fernandez Wenxin Zheng Sean Pitroda Steven J. Chmura Jason J. Luke Martin Forde Yuzhu Hou Byron Burnette Helena Mauceri Israel Lowy Tasha Sims Nikolai Khodarev Yang-Xin Fu Ralph R. Weichselbaum Tumor-reprogrammed resident T cells resist radiation to control tumors
description	Lymphocytes are considered one of the most radiosensitive cell types in the body. Here the authors show that unlike circulating lymphocytes, tumor-infiltrating T cells survive therapeutic doses of irradiation, remaining functional and contributing to radiotherapy induced anti-tumor immunity.
format	article
author	Ainhoa Arina Michael Beckett Christian Fernandez Wenxin Zheng Sean Pitroda Steven J. Chmura Jason J. Luke Martin Forde Yuzhu Hou Byron Burnette Helena Mauceri Israel Lowy Tasha Sims Nikolai Khodarev Yang-Xin Fu Ralph R. Weichselbaum
author_facet	Ainhoa Arina Michael Beckett Christian Fernandez Wenxin Zheng Sean Pitroda Steven J. Chmura Jason J. Luke Martin Forde Yuzhu Hou Byron Burnette Helena Mauceri Israel Lowy Tasha Sims Nikolai Khodarev Yang-Xin Fu Ralph R. Weichselbaum
author_sort	Ainhoa Arina
title	Tumor-reprogrammed resident T cells resist radiation to control tumors
title_short	Tumor-reprogrammed resident T cells resist radiation to control tumors
title_full	Tumor-reprogrammed resident T cells resist radiation to control tumors
title_fullStr	Tumor-reprogrammed resident T cells resist radiation to control tumors
title_full_unstemmed	Tumor-reprogrammed resident T cells resist radiation to control tumors
title_sort	tumor-reprogrammed resident t cells resist radiation to control tumors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d33bd7c45d314883a3946267882043c5
work_keys_str_mv	AT ainhoaarina tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT michaelbeckett tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT christianfernandez tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT wenxinzheng tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT seanpitroda tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT stevenjchmura tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT jasonjluke tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT martinforde tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT yuzhuhou tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT byronburnette tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT helenamauceri tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT israellowy tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT tashasims tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT nikolaikhodarev tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT yangxinfu tumorreprogrammedresidenttcellsresistradiationtocontroltumors AT ralphrweichselbaum tumorreprogrammedresidenttcellsresistradiationtocontroltumors
_version_	1718390326115172352

Tumor-reprogrammed resident T cells resist radiation to control tumors

Ejemplares similares