Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells

Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells

Spontaneous AP (action potential) firing of sinoatrial nodal cells (SANC) is critically dependent on protein kinase A (PKA) and Ca<sup>2+</sup>/calmodulin-dependent protein kinase II (CaMKII)-dependent protein phosphorylation, which are required for the generation of spontaneous, diastol...

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Bibliographic Details
Main Authors: Syevda Tagirova Sirenko, Ihor Zahanich, Yue Li, Yevgeniya O. Lukyanenko, Alexey E. Lyashkov, Bruce D. Ziman, Kirill V. Tarasov, Antoine Younes, Daniel R. Riordon, Yelena S. Tarasova, Dongmei Yang, Tatiana M. Vinogradova, Victor A. Maltsev, Edward G. Lakatta
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
sinoatrial node cells
local Ca<sup>2+</sup> releases
phosphoprotein phosphatase
endogenous phosphatase inhibitors
calyculin A
okadaic acid
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/d34e3e9a556b4610af29e09b6ffdc8e6
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