Machine learning classifies predictive kinematic features in a mouse model of neurodegeneration

Abstract Motor deficits are observed in Alzheimer’s disease (AD) prior to the appearance of cognitive symptoms. To investigate the role of amyloid proteins in gait disturbances, we characterized locomotion in APP-overexpressing transgenic J20 mice. We used three-dimensional motion capture to charact...

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Autores principales: Ruyi Huang, Ali A. Nikooyan, Bo Xu, M. Selvan Joseph, Hamidreza Ghasemi Damavandi, Nathan von Trotha, Lilian Li, Ashok Bhattarai, Deeba Zadeh, Yeji Seo, Xingquan Liu, Patrick A. Truong, Edward H. Koo, J. C. Leiter, Daniel C. Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d361dba0120d4531af8263892c02a303
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