The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats

Background/objectives: Recent data suggest a role for heparanase in several proteinuric conditions. An increased glomerular heparanase expression is associated with loss of heparan sulfate in the glomerular basement membrane (GBM). The aim of the present study was to investigate the renal effects of...

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Autores principales:	Roshan-Milani S., Khalilpour J., Fard A. Abdollahzade
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	heparanase diabetic nephropathy sulodexide urine protein urine glycosaminoglycan Medicine R
Acceso en línea:	https://doaj.org/article/d37568e71c8444bbbb5bf2c8fc19d5ec
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spelling	oai:doaj.org-article:d37568e71c8444bbbb5bf2c8fc19d5ec2021-12-02T19:05:13ZThe Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats0324-175010.2478/amb-2019-0017https://doaj.org/article/d37568e71c8444bbbb5bf2c8fc19d5ec2019-05-01T00:00:00Zhttps://doi.org/10.2478/amb-2019-0017https://doaj.org/toc/0324-1750Background/objectives: Recent data suggest a role for heparanase in several proteinuric conditions. An increased glomerular heparanase expression is associated with loss of heparan sulfate in the glomerular basement membrane (GBM). The aim of the present study was to investigate the renal effects of heparanase inhibition in a diabetic experimental model.Roshan-Milani S.Khalilpour J.Fard A. AbdollahzadeSciendoarticleheparanasediabetic nephropathysulodexideurine proteinurine glycosaminoglycanMedicineRENActa Medica Bulgarica, Vol 46, Iss 2, Pp 41-46 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	heparanase diabetic nephropathy sulodexide urine protein urine glycosaminoglycan Medicine R
spellingShingle	heparanase diabetic nephropathy sulodexide urine protein urine glycosaminoglycan Medicine R Roshan-Milani S. Khalilpour J. Fard A. Abdollahzade The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats
description	Background/objectives: Recent data suggest a role for heparanase in several proteinuric conditions. An increased glomerular heparanase expression is associated with loss of heparan sulfate in the glomerular basement membrane (GBM). The aim of the present study was to investigate the renal effects of heparanase inhibition in a diabetic experimental model.
format	article
author	Roshan-Milani S. Khalilpour J. Fard A. Abdollahzade
author_facet	Roshan-Milani S. Khalilpour J. Fard A. Abdollahzade
author_sort	Roshan-Milani S.
title	The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats
title_short	The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats
title_full	The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats
title_fullStr	The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats
title_full_unstemmed	The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats
title_sort	heparanase inhibitor (sulodexide) decreases urine glycosaminoglycan excretion and mitigates functional and histological renal damages in diabetic rats
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/d37568e71c8444bbbb5bf2c8fc19d5ec
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The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats

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