Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking

Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Previously collected frozen serum samples were tested...

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Autores principales:	Jun Wang, David V. Conti, Marta Epeldegui, Miina Ollikainen, Rachel F. Tyndale, Amie Eunah Hwang, Larry Magpantay, Thomas McCulloch Mack, Otoniel Martinez-Maza, Jaakko Kaprio, Wendy Cozen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	TARC/CCL17 BAFF MCP1 spg130 smoking Hodgkin lymphoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d39cf07847d14c51a74eed5b147fa4f7
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spelling	oai:doaj.org-article:d39cf07847d14c51a74eed5b147fa4f72021-11-11T15:30:00ZLymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking10.3390/cancers132153952072-6694https://doaj.org/article/d39cf07847d14c51a74eed5b147fa4f72021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5395https://doaj.org/toc/2072-6694Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Previously collected frozen serum samples were tested for cotinine to validate self-reported smoking history. In total, 27 immune biomarkers were assayed using the Luminex Multiplex platform (R & D Systems). Current and non-current smokers were defined by a serum cotinine concentration of >3.08 ng/mL and ≤3.08 ng/mL, respectively. Associations between biomarkers and smoking were assessed using linear mixed models to estimate beta coefficients and standard errors, adjusting for age, sex and twin pair as a random effect. There were 55 never smokers, 43 current smokers and 36 former smokers. CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (<i>p</i> < 0.05) associated with current smoking and correlated with increasing cotinine concentrations (<i>P</i><sub>trend</sub> < 0.05). The strongest association was observed for CCL17/TARC (<i>P</i><sub>trend</sub> = 0.0001). Immune biomarker levels were similar in former and never smokers. Current smoking is associated with increased levels of lymphoma-associated biomarkers, suggesting a possible mechanism for the link between smoking and risk of these two B-cell lymphomas.Jun WangDavid V. ContiMarta EpeldeguiMiina OllikainenRachel F. TyndaleAmie Eunah HwangLarry MagpantayThomas McCulloch MackOtoniel Martinez-MazaJaakko KaprioWendy CozenMDPI AGarticleTARC/CCL17BAFFMCP1spg130smokingHodgkin lymphomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5395, p 5395 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TARC/CCL17 BAFF MCP1 spg130 smoking Hodgkin lymphoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	TARC/CCL17 BAFF MCP1 spg130 smoking Hodgkin lymphoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jun Wang David V. Conti Marta Epeldegui Miina Ollikainen Rachel F. Tyndale Amie Eunah Hwang Larry Magpantay Thomas McCulloch Mack Otoniel Martinez-Maza Jaakko Kaprio Wendy Cozen Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
description	Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Previously collected frozen serum samples were tested for cotinine to validate self-reported smoking history. In total, 27 immune biomarkers were assayed using the Luminex Multiplex platform (R & D Systems). Current and non-current smokers were defined by a serum cotinine concentration of >3.08 ng/mL and ≤3.08 ng/mL, respectively. Associations between biomarkers and smoking were assessed using linear mixed models to estimate beta coefficients and standard errors, adjusting for age, sex and twin pair as a random effect. There were 55 never smokers, 43 current smokers and 36 former smokers. CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (<i>p</i> < 0.05) associated with current smoking and correlated with increasing cotinine concentrations (<i>P</i><sub>trend</sub> < 0.05). The strongest association was observed for CCL17/TARC (<i>P</i><sub>trend</sub> = 0.0001). Immune biomarker levels were similar in former and never smokers. Current smoking is associated with increased levels of lymphoma-associated biomarkers, suggesting a possible mechanism for the link between smoking and risk of these two B-cell lymphomas.
format	article
author	Jun Wang David V. Conti Marta Epeldegui Miina Ollikainen Rachel F. Tyndale Amie Eunah Hwang Larry Magpantay Thomas McCulloch Mack Otoniel Martinez-Maza Jaakko Kaprio Wendy Cozen
author_facet	Jun Wang David V. Conti Marta Epeldegui Miina Ollikainen Rachel F. Tyndale Amie Eunah Hwang Larry Magpantay Thomas McCulloch Mack Otoniel Martinez-Maza Jaakko Kaprio Wendy Cozen
author_sort	Jun Wang
title	Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
title_short	Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
title_full	Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
title_fullStr	Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
title_full_unstemmed	Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
title_sort	lymphoma-associated biomarkers are increased in current smokers in twin pairs discordant for smoking
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d39cf07847d14c51a74eed5b147fa4f7
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Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking

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