A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing

A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing

We have recently reported that a recombinant HIV-1NL4.3 containing Met-to-Ile change at codon 50 of integrase (IN) (IN:M50I) exhibits suppression of the virus release below 0.5% of WT HIV, and the released viral particles are replication-incompetent due to defects in Gag/GagPol processing by inhibit...

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Autores principales: Jun Yang, Ming Hao, Muhammad A. Khan, Muhammad T. Rehman, Helene C. Highbarger, Qian Chen, Suranjana Goswami, Brad T. Sherman, Catherine A. Rehm, Robin L. Dewar, Weizhong Chang, Tomozumi Imamichi
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
polymorphisms
integrase
M50I
V151I
autoprocessing
maturation
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/d3ccaabb87b0429cb3c47bc2cede4361
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https://doaj.org/article/d3ccaabb87b0429cb3c47bc2cede4361

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