A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells

A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells

Abstract An array of SARS-CoV-2 virus variants have been isolated, propagated and used in in vitro assays, in vivo animal studies and human clinical trials. Observations of working stocks of SARS-CoV-2 suggest that sequential propagation in Vero cells leads to critical changes in the region of the f...

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Bibliographic Details
Main Authors: Simon G. P. Funnell, Babak Afrough, John James Baczenas, Neil Berry, Kevin R. Bewley, Rebecca Bradford, Clint Florence, Yann Le Duff, Mark Lewis, Ryan V. Moriarty, Shelby L. O. Connor, Karen L. Osman, Steven Pullan, Sujatha Rashid, Kevin S. Richards, Kimberly J. Stemple, Ivana Knezevic
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/d3e61c501c474ee4bce5627f7aeb9067
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https://doaj.org/article/d3e61c501c474ee4bce5627f7aeb9067

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