A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

HIV infected cells persist for decades in patients under ART, but the mechanisms responsible remain unclear. Here, Reeves et al. use modeling approaches adapted from ecology to show that cellular proliferation, rather than viral replication, generates a majority of infected cells during ART.

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Autores principales: Daniel B. Reeves, Elizabeth R. Duke, Thor A. Wagner, Sarah E. Palmer, Adam M. Spivak, Joshua T. Schiffer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d3e708e779664bdfbeec752fe51d1be0
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