A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

HIV infected cells persist for decades in patients under ART, but the mechanisms responsible remain unclear. Here, Reeves et al. use modeling approaches adapted from ecology to show that cellular proliferation, rather than viral replication, generates a majority of infected cells during ART.

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Autores principales:	Daniel B. Reeves, Elizabeth R. Duke, Thor A. Wagner, Sarah E. Palmer, Adam M. Spivak, Joshua T. Schiffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d3e708e779664bdfbeec752fe51d1be0
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spelling	oai:doaj.org-article:d3e708e779664bdfbeec752fe51d1be02021-12-02T14:41:28ZA majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation10.1038/s41467-018-06843-52041-1723https://doaj.org/article/d3e708e779664bdfbeec752fe51d1be02018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06843-5https://doaj.org/toc/2041-1723HIV infected cells persist for decades in patients under ART, but the mechanisms responsible remain unclear. Here, Reeves et al. use modeling approaches adapted from ecology to show that cellular proliferation, rather than viral replication, generates a majority of infected cells during ART.Daniel B. ReevesElizabeth R. DukeThor A. WagnerSarah E. PalmerAdam M. SpivakJoshua T. SchifferNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel B. Reeves Elizabeth R. Duke Thor A. Wagner Sarah E. Palmer Adam M. Spivak Joshua T. Schiffer A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
description	HIV infected cells persist for decades in patients under ART, but the mechanisms responsible remain unclear. Here, Reeves et al. use modeling approaches adapted from ecology to show that cellular proliferation, rather than viral replication, generates a majority of infected cells during ART.
format	article
author	Daniel B. Reeves Elizabeth R. Duke Thor A. Wagner Sarah E. Palmer Adam M. Spivak Joshua T. Schiffer
author_facet	Daniel B. Reeves Elizabeth R. Duke Thor A. Wagner Sarah E. Palmer Adam M. Spivak Joshua T. Schiffer
author_sort	Daniel B. Reeves
title	A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
title_short	A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
title_full	A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
title_fullStr	A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
title_full_unstemmed	A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
title_sort	majority of hiv persistence during antiretroviral therapy is due to infected cell proliferation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d3e708e779664bdfbeec752fe51d1be0
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A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

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