Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography

The structures of many DNA polymerases is known, but PolD was a missing piece. Here, the authors report the crystal structure of this protein and use it to connect the DNA replication machinery with the transcription machinery in the same protein family.

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Bibliographic Details
Main Authors:	Ludovic Sauguet, Pierre Raia, Ghislaine Henneke, Marc Delarue
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/d4208d3f70564e7cb7b842ba3ac7b8a7
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id	oai:doaj.org-article:d4208d3f70564e7cb7b842ba3ac7b8a7
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spelling	oai:doaj.org-article:d4208d3f70564e7cb7b842ba3ac7b8a72021-12-02T15:34:10ZShared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography10.1038/ncomms122272041-1723https://doaj.org/article/d4208d3f70564e7cb7b842ba3ac7b8a72016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12227https://doaj.org/toc/2041-1723The structures of many DNA polymerases is known, but PolD was a missing piece. Here, the authors report the crystal structure of this protein and use it to connect the DNA replication machinery with the transcription machinery in the same protein family.Ludovic SauguetPierre RaiaGhislaine HennekeMarc DelarueNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ludovic Sauguet Pierre Raia Ghislaine Henneke Marc Delarue Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography
description	The structures of many DNA polymerases is known, but PolD was a missing piece. Here, the authors report the crystal structure of this protein and use it to connect the DNA replication machinery with the transcription machinery in the same protein family.
format	article
author	Ludovic Sauguet Pierre Raia Ghislaine Henneke Marc Delarue
author_facet	Ludovic Sauguet Pierre Raia Ghislaine Henneke Marc Delarue
author_sort	Ludovic Sauguet
title	Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography
title_short	Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography
title_full	Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography
title_fullStr	Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography
title_full_unstemmed	Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography
title_sort	shared active site architecture between archaeal pold and multi-subunit rna polymerases revealed by x-ray crystallography
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d4208d3f70564e7cb7b842ba3ac7b8a7
work_keys_str_mv	AT ludovicsauguet sharedactivesitearchitecturebetweenarchaealpoldandmultisubunitrnapolymerasesrevealedbyxraycrystallography AT pierreraia sharedactivesitearchitecturebetweenarchaealpoldandmultisubunitrnapolymerasesrevealedbyxraycrystallography AT ghislainehenneke sharedactivesitearchitecturebetweenarchaealpoldandmultisubunitrnapolymerasesrevealedbyxraycrystallography AT marcdelarue sharedactivesitearchitecturebetweenarchaealpoldandmultisubunitrnapolymerasesrevealedbyxraycrystallography
_version_	1718386930372050944

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography

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