The key role of genomics in modern vaccine and drug design for emerging infectious diseases.

It can be argued that the arrival of the "genomics era" has significantly shifted the paradigm of vaccine and therapeutics development from microbiological to sequence-based approaches. Genome sequences provide a previously unattainable route to investigate the mechanisms that underpin pat...

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Autores principales:	Kate L Seib, Gordon Dougan, Rino Rappuoli
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/d431ef2b010d46919ca20aac99614496
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spelling	oai:doaj.org-article:d431ef2b010d46919ca20aac996144962021-12-02T20:03:08ZThe key role of genomics in modern vaccine and drug design for emerging infectious diseases.1553-73901553-740410.1371/journal.pgen.1000612https://doaj.org/article/d431ef2b010d46919ca20aac996144962009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19855822/pdf/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404It can be argued that the arrival of the "genomics era" has significantly shifted the paradigm of vaccine and therapeutics development from microbiological to sequence-based approaches. Genome sequences provide a previously unattainable route to investigate the mechanisms that underpin pathogenesis. Genomics, transcriptomics, metabolomics, structural genomics, proteomics, and immunomics are being exploited to perfect the identification of targets, to design new vaccines and drugs, and to predict their effects in patients. Furthermore, human genomics and related studies are providing insights into aspects of host biology that are important in infectious disease. This ever-growing body of genomic data and new genome-based approaches will play a critical role in the future to enable timely development of vaccines and therapeutics to control emerging infectious diseases.Kate L SeibGordon DouganRino RappuoliPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 5, Iss 10, p e1000612 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Kate L Seib Gordon Dougan Rino Rappuoli The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
description	It can be argued that the arrival of the "genomics era" has significantly shifted the paradigm of vaccine and therapeutics development from microbiological to sequence-based approaches. Genome sequences provide a previously unattainable route to investigate the mechanisms that underpin pathogenesis. Genomics, transcriptomics, metabolomics, structural genomics, proteomics, and immunomics are being exploited to perfect the identification of targets, to design new vaccines and drugs, and to predict their effects in patients. Furthermore, human genomics and related studies are providing insights into aspects of host biology that are important in infectious disease. This ever-growing body of genomic data and new genome-based approaches will play a critical role in the future to enable timely development of vaccines and therapeutics to control emerging infectious diseases.
format	article
author	Kate L Seib Gordon Dougan Rino Rappuoli
author_facet	Kate L Seib Gordon Dougan Rino Rappuoli
author_sort	Kate L Seib
title	The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
title_short	The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
title_full	The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
title_fullStr	The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
title_full_unstemmed	The key role of genomics in modern vaccine and drug design for emerging infectious diseases.
title_sort	key role of genomics in modern vaccine and drug design for emerging infectious diseases.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/d431ef2b010d46919ca20aac99614496
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The key role of genomics in modern vaccine and drug design for emerging infectious diseases.

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